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KMID : 1155520140090030185
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Anesthesia and Pain Medicine
2014 Volume.9 No. 3 p.185 ~ p.192
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Effect of perioperative infusion of lidocaine vs. dexmedetomidine on reduced consumption of postoperative analgesics after laparoscopic cholecystectomy
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Cho Kwang-Rae
Lee Jeong-Han
Kim Myoung-Hun
Lee Won-Jin
Lim Se-Hun
Lee Kun-Moo
Ki Seung-Hee
Kim Jong-Han
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Abstract
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Background: Postoperative pain is the most common complaint of patients following laparoscopic cholecystectomy (LC). Intrave-nous lidocaine has analgesic, anti-hyperalgesic, and anti-inflamma-tory effects, and dexmedetomidine has anti-nociceptive and analge-sic sparing effects. We evaluated the effects of perioperative intra-venous infusion of lidocaine and dexmedetomidine on postoperative pain control and analgesic consumption after LC.
Methods:Eighty-four patients, aged 20?60 years, who were undergoing elective LC were assigned randomly to three groups (n = 28 in each). The patients in group L received an intravenous lidocaine bolus of 1.5 mg/kg and then continuous infusion of 2 mg/kg/hr. The group D received an intravenous dexmedetomidine bolus of 1 μg/kg, followed by continuous infusion of 0.4 μg/kg/hr. The group N received saline as described for group L. Bolus doses were given during the 10 minutes before the induction of anesthesia, followed by continuous infusion until end of the surgery. Visual analogue scale (VAS) score and postoperative analgesics consump-tion were evaluated during 24 hours after the surgery.
Results: No significant difference was observed in VAS score among the groups during the first 24 hr after LC. The amount of fentanyl consumption in the post-anesthesia care unit was significantly less in groups L and D compared to group N.
Conclusions: Both perioperative intravenous infusion of dexme-detomidine and lidocaine reduced postoperative requirements of fentanyl in the early post-operative period after LC. However, there was no significant difference between dexmedetomidine and lidocaine in the analgesic sparing effect.
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KEYWORD
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Dexmedetomidine, Laparoscopic cholecystectomy, Lidocaine, Postoperative pain
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